Palavras-chave
liberação tópica
feridas diabéticas
úlceras diabéticas
cicatrização
Como Citar
Resumo
O diabetes mellitus (DM) é uma doença crônica que afeta milhões globalmente, reduzindo a qualidade de vida e causando complicações graves, como feridas diabéticas (FDs). Essas feridas, de difícil cicatrização, são suscetíveis a infecções, frequentemente levando a amputações de membros inferiores e altos custos de tratamento. As opções terapêuticas atuais para FDs são limitadas, destacando a necessidade de novas abordagens. Nanopartículas (NPs), uma inovação da Nanotecnologia, mostram potencial promissor na cicatrização de FDs. Estudos científicos indicam que NPs podem melhorar a liberação de ativos cicatrizantes, aumentar sua solubilidade e estabilidade e melhorar a penetração na pele, elevando a eficácia do tratamento e reduzindo efeitos adversos. Esta revisão bibliográfica de 28 artigos publicados nos últimos 10 anos analisou a liberação de ativos, atividade antimicrobiana, segurança e eficácia de NPs em modelos in vitro e in vivo, mostrando que NPs podem otimizar a terapia cicatrizante de FDs e reduzir complicações em pacientes diabéticos.
Referências
ABDELKADER, D. H.; TAMBUWALA, M. M.; MITCHELL, C. A.; OSMAN, M. A.; EL-GIZAWY, S. A.; FAHEEM, A. M.; EL-TANANI, M.; MCCARRON, P. A. Enhanced cutaneous wound healing in rats following topical delivery of insulin-loaded nanoparticles embedded in poly (vinyl alcohol)-borate hydrogels. Drug delivery and translational research, [S. l.], v. 8, n. 5, p. 1053-1065, 2018. DOI: https://doi.org/10.1007/s13346-018-0554-0
ARANTES, V. T. et al. Retinoic acid-loaded solid lipid nanoparticles surrounded by chitosan film support diabetic wound healing in vivo study. Colloids and surfaces. B, Biointerfaces, [S. l.], v. 188, n. 110749, p. 110749, 2020. DOI: https://doi.org/10.1016/j.colsurfb.2019.110749
EL-SALAMOUNI, N. S.; GOWAYED, M. A.; SEIFFEIN, N. L.; ABDEL-MONEIM, R.; KAMEL, M. A.; LABIB, G. S. Valsartan solid lipid nanoparticles integrated hydrogel: A challenging repurposed use in the treatment of diabetic foot ulcer, in-vitro/in-vivo experimental study. International journal of pharmaceutics, [S. l.], v. 592, n. 120091, p. 120091, 2021. DOI: https://doi.org/10.1016/j.ijpharm.2020.120091
EREL-AKBABA, G. AKABABA, H.; KESELIK, E.; BAHCECI, S. A.; SENYIGIT, Z.; TEMIZ, T. K. Octaarginine functionalized nanoencapsulated system: In vitro and in vivo evaluation of bFGF loaded formulation for wound healing. Journal of Drug Delivery Science and Technology, [S. l.], v. 71, 2022. DOI: https://doi.org/10.1016/j.jddst.2022.103343
FATIMA, F. et al. Design and evaluation of solid lipid nanoparticles loaded topical gels: Repurpose of fluoxetine in diabetic wound healing. Gels, Basel, v. 9, n. 1, p. 21, 2022. DOI: https://doi.org/10.3390/gels9010021
GAINZA, G.; PASTOR, M.; AGUIRRE, J. J.; VILLULLAS, S.; PEDRAZ, J. L.; HERNANDEZ, R. M.; IGARTUA, M. A novel strategy for the treatment of chronic wounds based on the topical administration of rhEGF-loaded lipid nanoparticles: In vitro bioactivity and in vivo effectiveness in healing-impaired db/db mice. Journal of controlled release, [S. l.], v. 185, p. 51-61, 2014. DOI: https://doi.org/10.1016/j.jconrel.2014.04.032
GHASEMIYEH, P.; MOHAMMADI-SAMANI, S. Potential of nanoparticles as permeation enhancers and targeted delivery options for skin: advantages and disadvantages. Drug Design, Development and Therapy, [S. l.], v. 14, p. 3271–3289, 2020. DOI https://doi.org/10.2147/DDDT.S264648
HAJIMIRI, M. et al. Preparation of hydrogel embedded polymer-growth factor conjugated nanoparticles as a diabetic wound dressing. Drug development and industrial pharmacy, [S. l.], v. 42, n. 5, p. 707-719, 2016. DOI: https://doi.org/10.3109/03639045.2015.1075030
HASAN, N. et al. PEI/NONOates-doped PLGA nanoparticles for eradicating methicillin-resistant Staphylococcus aureus biofilm in diabetic wounds via binding to the biofilm matrix. Materials science & engineering. C, [S. l.], v. 103, n. 109741, p. 109741, 2019. DOI: https://doi.org/10.1016/j.msec.2019.109741
JIANG, J. S. et al. Patient-driven discovery of CCN1 to rescue cutaneous wound healing in diabetes via the intracellular EIF3A/CCN1/ATG7 signaling by nanoparticle-enabled delivery. Biomaterials, [S. l.], v. 288, 2022. DOI: https://doi.org/10.1016/j.biomaterials.2022.121698
KAMAR, S. S.; ABDEL-KADER, D. H.; RASHED, L. A. (Ed.). Beneficial effect of Curcumin Nanoparticles-Hydrogel on excisional skin wound healing in type-I diabetic rat: Histological and immunohistochemical studies, Annals of Anatomy. Annals of Anatomy - Anatomischer Anzeiger, [S. l.], v. 222, p. 94-102, 2019. https://doi.org/10.1016/j.aanat.2018.11.005
KAUR, P. et al. Novel nano-insulin formulation modulates cytokine secretion and remodeling to accelerate diabetic wound healing. Nanomedicine: nanotechnology, biology, and medicine, [S. l.], v. 15, n. 1, p. 47-57, 2019. DOI: https://doi.org/10.1016/j.nano.2018.08.013
LEE, H.-J. JEONG, M.; NA, Y.-G.; KIM, S.-J, LEE, H.-K.; CHO, C.-W. An EGF- and curcumin-co-encapsulated nanostructured lipid carrier accelerates chronic-wound healing in diabetic rats. Molecules, Basel, v. 25, n. 20, p. 4610, 2020. DOI: https://doi.org/10.3390/molecules25204610
LI, S. et al. Calcium ion cross-linked sodium alginate hydrogels containing deferoxamine and copper nanoparticles for diabetic wound healing. International Journal of Biological Macromolecules, [S. l.], v. 202, 2022. DOI: https://doi.org/10.1016/j.ijbiomac.2022.01.080
LOSI, P. BRIGANTI, E.; ERRICO, C.; LISELLA, A.; SANGUINETTI, E.; CHIELLINI, F.; SOLDANI, G. Fibrin-based scaffold incorporating VEGF- and bFGF-loaded nanoparticles stimulates wound healing in diabetic mice. Acta biomaterialia, [S. l.], v. 9, n. 8, p. 7814-7821, 2013. DOI: https://doi.org/10.1016/j.actbio.2013.04.019
MAATOUK, B.; JAFFA, M. A.; KARAM, M.; FAHS, D.; NOUR-ELDINE, W.; HASAN, A.; JAFFA, A. A.; MHANNA, R. Sulfated alginate/polycaprolactone double-emulsion nanoparticles for enhanced delivery of heparin-binding growth factors in wound healing applications. Colloids and surfaces. B, Biointerfaces, [S. l.], v. 208, n. 112105, p. 112105, 2021. DOI: https://doi.org/10.1016/j.colsurfb.2021.112105
MANNE, A. A.; ARIGELA, B.; GIDUTURI, A. K.; KOMARAVOLU, R. K.; MANGAMURI, U.; PODA, S. Pterocarpus marsupium Roxburgh heartwood extract/chitosan nanoparticles loaded hydrogel as an innovative wound healing agent in the diabetic rat model. Materials today. Communications, [S. l.], v. 26, n. 101916, p. 101916, 2021. DOI: https://doi.org/10.1016/j.mtcomm.2020.101916
MONTASER, A. S.; ABDEL-MOHSEN, A. M.; RAMADAN, M. A.; SLEEM, A. A.; SAHFFIE, N. M.; JANCAR, J.; HEBEISH, A. Preparation and characterization of alginate/silver/nicotinamide nanocomposites for treating diabetic wounds. International journal of biological macromolecules, [S. l.], v. 92, p. 739-747, 2016. DOI: https://doi.org/10.1016/j.ijbiomac.2016.07.050
MOTAWEA, A.; EL-GAWAD, A.; BORG, T.; MOTAWEA, M.; TARSHOBY, M. The impact of topical phenytoin loaded nanostructured lipid carriers in diabetic foot ulceration. The Foot, Edinburgh, v. 40, p. 14-21, 2019. DOI: https://doi.org/10.1016/j.foot.2019.03.007
NOR AZLAN, A. Y. H.; KATAS, H.; HABIDEEN, N. H.; BUSRA, M. F. Dual-action of thermoresponsive gels containing DsiRNA-loaded gold nanoparticles for diabetic wound therapy: Characterization, in vitro safety and healing efficacy. Saudi Pharmaceutical Journal, [S. l.], v. 28, n. 11, p. 1420-1430, 2020. DOI: https://doi.org/10.1016/j.jsps.2020.09.007
PANDA, D. S.; EID, H. M.; ELKOMY, M. H.; KHAMES, A.; HASSAN, R. M.; EL-ELA, F. I. A.; YASSIN, H. A. Berberine encapsulated lecithin–chitosan nanoparticles as innovative wound healing agent in type II diabetes. Pharmaceutics, [S. l.], v. 13, n. 8, p. 1197, 2021. DOI: https://doi.org/10.3390/pharmaceutics13081197
QAYOOM, A.; ANEESHA, V. A.; ANAGHA, S.; DAR, J. A.; KUMAR, P.; KUMAR, D. Lecithin-based deferoxamine nanoparticles accelerated cutaneous wound healing in diabetic rats. European Journal of Pharmacology, [S. l.], v. 858, n. 172478, p. 172478, 2019. DOI: https://doi.org/10.1016/j.ejphar.2019.172478
RABBANI, P. S. et al. Novel lipoproteoplex delivers Keap1 siRNA based gene therapy to accelerate diabetic wound healing. Biomaterials, [S. l.], v. 132, p. 1-15, 2017. DOI: https://doi.org/10.1016/j.biomaterials.2017.04.001
SHEIR, M. M.; NASRA, M. M. A.; ABDALLAH, O. Y. Phenytoin-loaded bioactive nanoparticles for the treatment of diabetic pressure ulcers: formulation and in vitro/in vivo evaluation. Drug delivery and translational research, [S. l.], v. 12, n. 12, p. 2936-2949, 2022. DOI: https://doi.org/10.1007/s13346-022-01156-z
SOLIMAN, W. E. ELSEWEDY, H. S.; YOUNIS, N. S.; SHINU, P.; ELSAWY, L. E.; RAMADAN, H. A. Evaluating antimicrobial activity and wound healing effect of rod-shaped nanoparticles. Polymers, [S. l.], v. 14, n. 13, p. 2637, 2022. DOI: https://doi.org/10.3390/polym14132637
STAGER, M. A. et al. Photopolymerized zwitterionic hydrogels with a sustained delivery of cerium oxide nanoparticle-miR146a conjugate accelerate diabetic wound healing. ACS Applied Biomaterials, [S. l.], v. 5, n. 3, p. 1092-1103, feb. 2022. DOI: https://doi.org/10.1021/acsabm.1c01155
SUN, H. et al. Zinc alginate hydrogels with embedded RL-QN15 peptide-loaded hollow polydopamine nanoparticles for diabetic wound healing therapy. Materials & design, [S. l.], v. 222, n. 111085, p. 111085, 2022. DOI: https://doi.org/10.1016/j.matdes.2022.111085
WANG, S.; YAN, C.; ZHANG, X.; SHI, L.; LUO, G.; DENG, J. Antimicrobial peptide modification enhances the gene delivery and bactericidal efficiency of gold nanoparticles for accelerating diabetic wound healing. Biomaterials science, [S. l.], v. 6, n. 10, p. 2757-2772, 2018. DOI: https://doi.org/10.1039/C8BM00807H
YANG, Z.; CHAN, H.; YANG, P.; SHEN, X.; HU, Y.; CHENG, Y.; YAO, H.; ZHANG, Z. Nano-oxygenated hydrogels for locally and permeably hypoxia relieving to heal chronic wounds. Biomaterials, [S. l.], v. 282, n. 121401, p. 121401, 2022. DOI: https://doi.org/10.1016/j.biomaterials.2022.121401
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Copyright (c) 2024 Maria Bernadete Pierre, Adrielle Rodrigues da Silva